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Periodic evaluation of blood pressure is advisable during concurrent use of methylphenidate and clonidine, particularly during initial coadministration and after dosage increases of methylphenidate. Rufus should also be taken outside to urinate more than twice a day and should never be corrected with punishment.

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Treatment duration has varied across clinical trials, generally ranging from 3 to 10 weeks.

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Moderate Cyclobenzaprine is structurally related to the tricyclic antidepressants and Clonidine's antihypertensive effect can be reduced by TCAs. The lymphoblast contains a prominent nucleolus with chromatin that is thinly stippled and less clumped than chromatin present in a lymphocyte.

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  1. Extreme caution should be exercised if apomorphine is used concurrently with antihypertensive agents, or vasodilators such as nitrates.

  2. Clonidine appears generally inferior to buprenorphine or methadone taper for opiate withdrawal treatment; however, clonidine is more effective than placebo and a useful alternative to buprenorphine for targeting noradrenergic-mediated withdrawal symptoms such as nausea, vomiting, diarrhea, cramps, and sweating. Clonidine administered epidurally produces a dose-dependent analgesia that is not antagonized by opiate antagonists.